WORESANA® ingredients are technically the result of a healthy microbial development process. Representing a healthy artificial biofilm mixture, they deliver a symbiotic group of microorganisms that aid in redeveloping the cutaneous environment.
During production our ferment is inactivated at its point of highest activity through lysis of the microorganisms, leaving a prebiotic substrate that selectively promotes cutaneous microbial growth. This specific activity became visible in a test of the metabolism activity. A highly stable lactobacilli strain culture was grown under specific conditions for a duration of 24 hours. The degree of activity was examined every two hours.
The results clearly showed that the microbial community that received 5% of WORESANA® developed faster and more stable than the reference community without WORESANA®. An explanation for this is in the WORESANA® lactic acid fermentation. Lactic acid bacteria (LAB) produce bacteriocins and antifungal compounds, comparable to those present in the skin microbiome, which prevent the excessive growth of potentially harmful bacterial competitors.
The different bacteriocins do this by either promoting a competitive inhibition which destroys pathogens, or by stimulating immunomodulation. Bacteriocins are not affected through lysis. On top of that our tests showed promising results regarding the time window during redevelopment of the culture in which different WORESANA® ingredients showed their highest influence. This is caused as the result of different bacteriocins that arise from different starting materials.
The microbial challenge tests have proven that WORESANA® ingredients show antimicrobial activity on Staphylococcus aureus, P. acnes and Malassezia, probing both selectively enhancing and inhibiting microbial activities. The wide range of acids of WORESANA® ingredients are not nlylowering and balancing the skins pH Value and creating an unfavourable acidic environment for pathogenic microorganisms, but they also absorb excess skin fat and gently exfoliate dead skin cells, providing ideal surface conditions.